No improvement by amphetamine on learned non‐use, attempts, success or movement in skilled reaching by the rat after motor cortex stroke
Identifieur interne : 002550 ( Main/Exploration ); précédent : 002549; suivant : 002551No improvement by amphetamine on learned non‐use, attempts, success or movement in skilled reaching by the rat after motor cortex stroke
Auteurs : Mariam Alaverdashvili [Canada] ; Diana H. Lim [Canada] ; Ian Q. Whishaw [Canada]Source :
- European Journal of Neuroscience [ 0953-816X ] ; 2007-06.
English descriptors
- KwdEn :
Abstract
Amphetamine (AMPH) has been proposed as a treatment for post‐stroke motor deficits when coupled with symptom‐relevant physical rehabilitation. Whereas a number of experimental studies report improvements in endpoint measures of skilled reaching for food by rats, there has been no assessment of whether beneficial effects extend to overcoming learned non‐use of the limb in the acute post‐stroke period or to the qualitative deficits in movement in the chronic post‐stroke period. In addition to evaluating the effects of AMPH on success, these were the objectives of the present study. In three different reaching experiments, groups of rats were pre‐trained in skilled reaching for food prior to receiving a motor cortex stroke via pial removal. Postoperatively the rats received periodic AMPH treatment and daily rehabilitation. In the acute post‐stroke period, AMPH failed to prevent the development of learned non‐use of the limb, and in the acute and chronic period failed to improve recovery of reaching success, and also failed to improve the qualitative aspects of reaching movements. Nevertheless, AMPH did enhance adjunct non‐reaching movements of locomotion, rearing and turning. The results are discussed in relation to the idea that the beneficial effects of post‐stroke AMPH treatment do not extend to all movements, especially the movements of a forelimb in retrieving and consuming food.
Url:
DOI: 10.1111/j.1460-9568.2007.05594.x
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 001E70
- to stream Istex, to step Curation: 001E70
- to stream Istex, to step Checkpoint: 000A30
- to stream Main, to step Merge: 002793
- to stream Main, to step Curation: 002550
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">No improvement by amphetamine on learned non‐use, attempts, success or movement in skilled reaching by the rat after motor cortex stroke</title><author><name sortKey="Alaverdashvili, Mariam" sort="Alaverdashvili, Mariam" uniqKey="Alaverdashvili M" first="Mariam" last="Alaverdashvili">Mariam Alaverdashvili</name></author><author><name sortKey="Lim, Diana H" sort="Lim, Diana H" uniqKey="Lim D" first="Diana H." last="Lim">Diana H. Lim</name></author><author><name sortKey="Whishaw, Ian Q" sort="Whishaw, Ian Q" uniqKey="Whishaw I" first="Ian Q." last="Whishaw">Ian Q. Whishaw</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:BE3891E8D3B490E19C73E256B893C5EA63A0BBCD</idno><date when="2007" year="2007">2007</date><idno type="doi">10.1111/j.1460-9568.2007.05594.x</idno><idno type="url">https://api-v5.istex.fr/document/BE3891E8D3B490E19C73E256B893C5EA63A0BBCD/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">001E70</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001E70</idno><idno type="wicri:Area/Istex/Curation">001E70</idno><idno type="wicri:Area/Istex/Checkpoint">000A30</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000A30</idno><idno type="wicri:doubleKey">0953-816X:2007:Alaverdashvili M:no:improvement:by</idno><idno type="wicri:Area/Main/Merge">002793</idno><idno type="wicri:Area/Main/Curation">002550</idno><idno type="wicri:Area/Main/Exploration">002550</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">No improvement by amphetamine on learned non‐use, attempts, success or movement in skilled reaching by the rat after motor cortex stroke</title><author><name sortKey="Alaverdashvili, Mariam" sort="Alaverdashvili, Mariam" uniqKey="Alaverdashvili M" first="Mariam" last="Alaverdashvili">Mariam Alaverdashvili</name><affiliation wicri:level="1"><country>Canada</country><wicri:regionArea>Department of Neuroscience, Canadian Centre for Behavioral Neurosciences, University of Lethbridge, Alberta</wicri:regionArea><wicri:noRegion>Alberta</wicri:noRegion></affiliation></author><author><name sortKey="Lim, Diana H" sort="Lim, Diana H" uniqKey="Lim D" first="Diana H." last="Lim">Diana H. Lim</name><affiliation wicri:level="1"><country>Canada</country><wicri:regionArea>Department of Neuroscience, Canadian Centre for Behavioral Neurosciences, University of Lethbridge, Alberta</wicri:regionArea><wicri:noRegion>Alberta</wicri:noRegion></affiliation></author><author><name sortKey="Whishaw, Ian Q" sort="Whishaw, Ian Q" uniqKey="Whishaw I" first="Ian Q." last="Whishaw">Ian Q. Whishaw</name><affiliation wicri:level="1"><country>Canada</country><wicri:regionArea>Department of Neuroscience, Canadian Centre for Behavioral Neurosciences, University of Lethbridge, Alberta</wicri:regionArea><wicri:noRegion>Alberta</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">European Journal of Neuroscience</title><idno type="ISSN">0953-816X</idno><idno type="eISSN">1460-9568</idno><imprint><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2007-06">2007-06</date><biblScope unit="volume">25</biblScope><biblScope unit="issue">11</biblScope><biblScope unit="page" from="3442">3442</biblScope><biblScope unit="page" to="3452">3452</biblScope></imprint><idno type="ISSN">0953-816X</idno></series><idno type="istex">BE3891E8D3B490E19C73E256B893C5EA63A0BBCD</idno><idno type="DOI">10.1111/j.1460-9568.2007.05594.x</idno><idno type="ArticleID">EJN5594</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0953-816X</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>amphetamine and motor cortex stroke</term><term>amphetamine and recovery</term><term>learned non‐use</term><term>qualitative measures of skilled reaching</term><term>upper extremities and stroke</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Amphetamine (AMPH) has been proposed as a treatment for post‐stroke motor deficits when coupled with symptom‐relevant physical rehabilitation. Whereas a number of experimental studies report improvements in endpoint measures of skilled reaching for food by rats, there has been no assessment of whether beneficial effects extend to overcoming learned non‐use of the limb in the acute post‐stroke period or to the qualitative deficits in movement in the chronic post‐stroke period. In addition to evaluating the effects of AMPH on success, these were the objectives of the present study. In three different reaching experiments, groups of rats were pre‐trained in skilled reaching for food prior to receiving a motor cortex stroke via pial removal. Postoperatively the rats received periodic AMPH treatment and daily rehabilitation. In the acute post‐stroke period, AMPH failed to prevent the development of learned non‐use of the limb, and in the acute and chronic period failed to improve recovery of reaching success, and also failed to improve the qualitative aspects of reaching movements. Nevertheless, AMPH did enhance adjunct non‐reaching movements of locomotion, rearing and turning. The results are discussed in relation to the idea that the beneficial effects of post‐stroke AMPH treatment do not extend to all movements, especially the movements of a forelimb in retrieving and consuming food.</div></front></TEI><affiliations><list><country><li>Canada</li></country></list><tree><country name="Canada"><noRegion><name sortKey="Alaverdashvili, Mariam" sort="Alaverdashvili, Mariam" uniqKey="Alaverdashvili M" first="Mariam" last="Alaverdashvili">Mariam Alaverdashvili</name></noRegion><name sortKey="Lim, Diana H" sort="Lim, Diana H" uniqKey="Lim D" first="Diana H." last="Lim">Diana H. Lim</name><name sortKey="Whishaw, Ian Q" sort="Whishaw, Ian Q" uniqKey="Whishaw I" first="Ian Q." last="Whishaw">Ian Q. Whishaw</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Canada/explor/ParkinsonCanadaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002550 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 002550 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Canada
|area= ParkinsonCanadaV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:BE3891E8D3B490E19C73E256B893C5EA63A0BBCD
|texte= No improvement by amphetamine on learned non‐use, attempts, success or movement in skilled reaching by the rat after motor cortex stroke
}}
| This area was generated with Dilib version V0.6.29. |  |